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No particular dose adjustment proposed when tofacitinib coadministered with potent CYP2C19 inhibitors; lower tofacitinib dose if coadministered with equally moderate CYP3A4 and potent CYP2C19 inhibitors .Hou et al (2005) analyzed the autonomic outcomes of modafinil in individuals. They found that modafinil impacts the locus coeruleus, which mediate